Crafted with XpresHAn Technology™, NEW Restylane® Defyne helps smooth out deep laugh lines (nasolabial folds and marionette lines). Using innovative cross-linking technology, Restylane Defyne is a hyaluronic acid dermal filler that is able to help restore a more youthful, natural-looking appearance, while helping you maintain your natural expressions.
Restylane® Defyne is for mid-to-deep injection into the facial tissue for the correction of moderate to severe deep facial wrinkles and folds, such as nasolabial folds, in patients over the age of 21.
How is Restylane® Defyne different?
As we age, our skin loses elasticity and the lines that run from the sides of the nose toward the corners of the mouth (nasolabial folds) and the lines that run from the corner of your mouth toward the chin (marionette lines) become more pronounced. Restylane Defyne is crafted with XpresHAn Technology™ to correct these deepened lines.3† The unique cross-linking of the gel in Restylane Defyne is also designed to help support your facial expressions—for natural-looking results that help maintain your natural movement.1,2
Are there any reasons why I should not use products within the Restylane® family? (Contraindications)
To ensure a safe procedure, your doctor will talk to you about your medical history to determine if you are an appropriate candidate for treatment. You should not use products within the Restylane family if:
What are the possible side effects?
The most commonly observed side effects are swelling, redness, pain, bruising, headache, tenderness, lump formation, and itching at the injection site. These are typically mild in severity and typically resolve in less than 7 days in nasolabial folds and less than 14 days in lips. Serious but rare side effects include delayed onset infections, recurrence of herpetic eruptions, and superficial necrosis at the injection site.
One of the risks with using this product is unintentional injection into a blood vessel. The chances of this happening are very small, but if it does happen, the complications can be serious, and may be permanent. These complications, which have been reported for facial injections, can include vision abnormalities, blindness, stroke, temporary scabs, or permanent scarring of the skin.
As with all skin injection procedures, there is a risk of infection.
|Treatment Type||Filler, Injectables|
|Treatment Problem or Condition||Facial Volume Loss, Fine Lines, Wrinkles|
|Skin Type||Aging Skin|
|Size||1 cc syringe|
Restylane Defyne is indicated for injection into the mid-to-deep dermis for correction of
moderate to severe, deep facial wrinkles and folds (such as nasolabial folds) in patients
over the age of 21.
- Restylane Defyne is contraindicated for patients with severe allergies manifested by a history of anaphylaxis or history or presence of multiple severe allergies.
- Restylane Defyne may contain trace amounts of gram-positive bacterial proteins and is contraindicated for patients with a history of allergies to such material.
- Restylane Defyne contains lidocaine and is contraindicated for patients with a history of allergies to such material.
Restylane® Defyne is a sterile, biodegradable, viscoelastic, non-pyrogenic, clear, colorless, and homogeneous soft hyaluronic acid gel with a high lifting capacity. The product has a sodium hyaluronate concentration of 20 mg/mL in phosphate buffered saline at pH 7 and contains 3 mg/mL lidocaine hydrochloride.